Scopulariopsis, a poorly known opportunistic fungus: spectrum of species in clinical samples and in vitro responses to antifungal drugs.
J Clin Microbiol, 2013/12;51(12):3937-43.
Sandoval-Denis M[1], Sutton DA, Fothergill AW, Cano-Lira J, Gené J, Decock CA, de Hoog GS, Guarro J
Affiliations
PMID: 24025910DOI: 10.1128/JCM.01927-13
Impact factor: 11.677
Abstract
Ninety-nine isolates of clinical origin, tentatively identified as Scopulariopsis or Microascus, were morphologically and molecularly characterized by a combined analysis of the D1/D2 domains of the 28S rRNA gene and a fragment of the elongation factor 1-α gene (EF1-α) sequences. The most prevalent species was Scopulariopsis brevicaulis (49.4%), followed by Scopulariopsis gracilis (14.4%), Scopulariopsis brumptii (7.2%), Microascus cinereus (5.2%), the Scopulariopsis candida species complex (3.1%), and Microascus cirrosus (2.1%). The most common anatomic sites of isolation were the respiratory tract (61.6%), superficial tissue (19.2%), and deep tissue or fluid samples (19.2%). The antifungal susceptibilities of the isolates to eight drugs were tested in vitro, with all the drugs generally showing poor activity.
MeSH terms
Antifungal Agents; Cluster Analysis; DNA, Fungal; DNA, Ribosomal; Genes, rRNA; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mycological Typing Techniques; Mycoses; Peptide Elongation Factor 1; Phylogeny; RNA, Fungal; RNA, Ribosomal; Scopulariopsis; Sequence Analysis, DNA
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