The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection.
Immunity, 2013/8/22;39(2):286-97.
Kim MV[1], Ouyang W, Liao W, Zhang MQ, Li MO
Affiliations
PMID: 23932570
Impact factor: 43.474
Abstract
Memory T cells protect hosts from pathogen reinfection, but how these cells emerge from a pool of antigen-experienced T cells is unclear. Here, we show that mice lacking the transcription factor Foxo1 in activated CD8+ T cells have defective secondary, but not primary, responses to Listeria monocytogenes infection. Compared to short-lived effector T cells, memory-precursor T cells expressed higher amounts of Foxo1, which promoted their generation and maintenance. Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 as Foxo1-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking. These findings demonstrate that Foxo1 is selectively incorporated into the genetic program that regulates memory CD8+ T cell responses to infection.
MeSH terms
Adoptive Transfer; Animals; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Cell Differentiation; Forkhead Box Protein O1; Forkhead Transcription Factors; Green Fluorescent Proteins; Hepatocyte Nuclear Factor 1-alpha; Immunologic Memory; Listeria monocytogenes; Listeriosis; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, CCR7; T Cell Transcription Factor 1
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