Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.
J Infect Dis, 2013/11/15;208(10):1664-8.
Herberg JA[1], Kaforou M, Gormley S, Sumner ER, Patel S, Jones KD, Paulus S, Fink C, Martinon-Torres F, Montana G, Wright VJ, Levin M
Affiliations
PMID: 23901082DOI: 10.1093/infdis/jit348
Impact factor: 7.759
Abstract
We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
Keywords: Peptide Chain Initiation; RSV; eIF-2 Kinase; gene expression profiling; influenza; microarray analysis; pediatric; respiratory tract infection
MeSH terms
Adolescent; Bacterial Infections; Child; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Protein Biosynthesis; Reproducibility of Results; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Signal Transduction
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