Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer.
Cancer Lett, 2013/10/10;339(2):270-8.
Chen YT[1], Ho CL, Chen PK, Chen YL, Chang CF
Affiliations
PMID: 23834814
Impact factor: 9.756
Abstract
The prevention of oral squamous cell carcinoma metastasis to improve overall patient survival has provided the rationale for biomarker development. We used the Transwell invasion assay to isolate a highly metastatic subpopulation, HSC-3-5 cells, with almost the same genetic background as HSC-3 cells but a higher metastatic capacity accompanied by cytoskeletal rearrangements and mesenchymal transformation. HSC-3-5 cells also showed tumorigenic and metastatic characteristics in vivo. In addition, Anterior gradient 2 (agr2), a pro-oncogenic signaling intermediate, was identified from gene expression profiling, and overexpression of AGR2 showed a positive correlation with oral tumor metastasis. Taken together, our data suggest that AGR2 may be a novel sensitive biomarker for metastatic oral cancer.
Keywords: Anterior gradient 2; HSC-3; Metastasis; Oral squamous cell carcinoma
MeSH terms
Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mouth Neoplasms; Mucoproteins; Neoplasm Metastasis; Neoplasm Staging; Oncogene Proteins; Proteins; Transplantation, Heterologous
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