Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model.
Mol Cell Biochem, 2013/11;383(1-2):13-20.
Affiliations
PMID: 23812844DOI: 10.1007/s11010-013-1746-z
Impact factor: 3.842
Abstract
Human mesenchymal stem cell (MSC)-conditioned medium (CM) was previously reported to affect the biology of tumor cells; however, the precise mechanisms remain unclear. Here, we show that MSCs secreted 40-100 nm particles, which have the typical characteristics of exosomes, and these MSC-derived exosomes promoted migration of the breast cancer cell line MCF7. Global gene expression profiling revealed that several cancer-related signaling pathways were upregulated after exosome treatment in MCF7, and the Wnt signaling pathway was further confirmed to be activated. Our findings demonstrated a new mechanism through which MSC-CM may contribute to tumor cell migration.
MeSH terms
Adipose Tissue; Breast Neoplasms; Cell Movement; Cell Proliferation; Exosomes; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mesenchymal Stem Cells; Models, Biological; Wnt Signaling Pathway
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