Complete sequences of two plasmids in a blaNDM-1-positive Klebsiella oxytoca isolate from Taiwan.
Antimicrob Agents Chemother, 2013/8;57(8):4072-6.
Huang TW[1], Wang JT, Lauderdale TL, Liao TL, Lai JF, Tan MC, Lin AC, Chen YT, Tsai SF, Chang SC
Affiliations
PMID: 23752513DOI: 10.1128/AAC.02266-12
Impact factor: 5.938
Abstract
Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (bla(CTX-M-3) and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.
MeSH terms
Aminoglycosides; Anti-Bacterial Agents; Conjugation, Genetic; Escherichia coli; Genes, Bacterial; Genes, MDR; Humans; Klebsiella Infections; Klebsiella oxytoca; Microbial Sensitivity Tests; Plasmids; Taiwan; beta-Lactamases
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