The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
Nat Genet, 2013/7;45(7):776-783.
Huang Y[1, 2], Li Y[3], Burt DW[2], Chen H[4], Zhang Y[3], Qian W[3], Kim H[5], Gan S[1], Zhao Y[1], Li J[3], Yi K[3], Feng H[4], Zhu P[4], Li B[3], Liu Q[1], Fairley S[6], Magor KE[7], Du Z[1], Hu X[1], Goodman L[3], Tafer H[8, 9], Vignal A[10], Lee T[5], Kim KW[11], Sheng Z[1], An Y[1], Searle S[6], Herrero J[12], Groenen MAM[13], Crooijmans RPMA[13], Faraut T[10], Cai Q[3], Webster RG[14], Aldridge JR[14], Warren WC[15], Bartschat S[8], Kehr S[8], Marz M[8], Stadler PF[8, 9], Smith J[2], Kraus RHS[16, 17], Zhao Y[1], Ren L[1], Fei J[1], Morisson M[10], Kaiser P[2], Griffin DK[18], Rao M[1], Pitel F[10], Wang J[3, 19], Li N[1]
Affiliations
PMID: 23749191DOI: 10.1038/ng.2657
Impact factor: 41.307
Abstract
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
MeSH terms
Animals; Base Sequence; Chickens; Disease Reservoirs; Disease Vectors; Ducks; Female; Geese; Genome; Host-Pathogen Interactions; Immunity; Influenza in Birds; Molecular Sequence Data; Phylogeny; Species Specificity; Transcriptome
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