Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population.
Genome Res, 2013/10;23(10):1663-74.
Schmitz RJ[1], He Y, Valdés-López O, Khan SM, Joshi T, Urich MA, Nery JR, Diers B, Xu D, Stacey G, Ecker JR
Affiliations
PMID: 23739894DOI: 10.1101/gr.152538.112
Impact factor: 9.438
Abstract
Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were identified. Linkage mapping of methylation states assessed from whole-genome bisulfite sequencing of 83 RILs uncovered widespread evidence for local methylQTL. This epigenomics approach provides a comprehensive study of the patterns and heritability of methylation variants in a complex genetic population over multiple generations, paving the way for understanding how methylation variants contribute to phenotypic variation.
MeSH terms
Arabidopsis; Cell Division; Chromosome Mapping; Cytosine; DNA Methylation; DNA Transposable Elements; DNA, Plant; DNA, Recombinant; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Plant; Genes, Plant; Genetic Variation; Genome, Plant; Genotype; Inbreeding; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sequence Analysis; Glycine max
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