New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.
Blood, 2013/6/20;121(25):5064-7.
Brandimarte L[1], Pierini V, Di Giacomo D, Borga C, Nozza F, Gorello P, Giordan M, Cazzaniga G, Te Kronnie G, La Starza R, Mecucci C
Affiliations
PMID: 23673860DOI: 10.1182/blood-2013-02-487256
Impact factor: 25.476
Abstract
The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific leukemic fusions generated from recurrent 11q23 and 11q14 chromosome translocations. Deep sequencing recently identified NAP1L1/12q21 as another MLLT10 partner in T-cell acute lymphoblastic leukemia (T-ALL). In pediatric T-ALL, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. Gene expression profile signatures of the HNRNPH1- and DDX3X-MLLT10 fusions placed them in the HOXA subgroup. Remarkably, they were highly similar only to PICALM-MLLT10-positive cases. The present study showed MLLT10 promiscuity in pediatric T-ALL and identified a specific MLLT10 signature within the HOXA subgroup.
MeSH terms
Child; DEAD-box RNA Helicases; Humans; In Situ Hybridization, Fluorescence; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transcriptome; Translocation, Genetic
More resources
EndNote: Download