Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria.
Emerg Infect Dis, 2013/5;19(5):802-5.
Bright AT[1], Alenazi T, Shokoples S, Tarning J, Paganotti GM, White NJ, Houston S, Winzeler EA, Yanow SK
Affiliations
PMID: 23648098DOI: 10.3201/eid1905.121852
Impact factor: 16.126
Abstract
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
Keywords: Plasmodium vivax; genetics; malaria; parasites; primaquine; relapse
MeSH terms
Adult; Antimalarials; Biotransformation; Chloroquine; Drug Tolerance; Genome, Protozoan; High-Throughput Nucleotide Sequencing; Humans; Malaria, Vivax; Male; Plasmodium vivax; Polymorphism, Single Nucleotide; Primaquine; Recurrence; Sequence Analysis, DNA
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