Intrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae.
Clin Microbiol Infect, 2013/5;19(5):E233-5.
Gomez S[1], Pasteran F, Faccone D, Bettiol M, Veliz O, De Belder D, Rapoport M, Gatti B, Petroni A, Corso A
Affiliations
PMID: 23402333DOI: 10.1111/1469-0691.12142
Impact factor: 13.31
Abstract
Two genetically related Klebsiella pneumoniae strains carrying OXA-type carbapenemases were isolated from a single patient 1 month apart. Kpn163 harboured OXA-163 and Kpn247 a new variant named OXA-247 that showed susceptibility to carbapenems and expanded-spectrum cephalosporins similar to OXA-48. Our epidemiological, biochemical and molecular results suggest the intrapatient emergence of blaOXA -247 from blaOXA -163.
MeSH terms
Adolescent; Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Cephalosporins; DNA, Bacterial; Female; Humans; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Epidemiology; Molecular Sequence Data; Sequence Analysis, DNA; beta-Lactam Resistance; beta-Lactamases
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