Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells.
Immunity, 2012/11/16;37(5):917-29.
Duffy D[1], Perrin H, Abadie V, Benhabiles N, Boissonnas A, Liard C, Descours B, Reboulleau D, Bonduelle O, Verrier B, Van Rooijen N, Combadière C, Combadière B
Affiliations
PMID: 23142782
Impact factor: 43.474
Abstract
The bone marrow (BM) has been identified as a possible organ for T cell priming, yet the fundamental mechanisms of a polyclonal immune response in the BM remain unknown. We found that after intradermal injection of modified vaccinia Ankara virus, unexpected sources of newly primed polyclonal virus-specific CD8(+), but not CD4(+), T cells were localized in the BM and the draining lymph nodes (dLNs) prior to blood circulation. We identified neutrophils as the virus-carrier cells from the dermis to the BM. In both neutrophil-depleted and Ccr1(-/-) mice, virus-specific BM CD8(+) responses were lost. Myeloid antigen-presenting cells were required for BM CD8(+) T cell priming. A systems biology analysis of dLN and BM virus-specific CD8(+) T cells revealed distinct transcriptional and multifunctional profiles for cells primed in each organ. We provide direct evidence for how antigen is transported to the BM, providing a source of virus-specific memory CD8(+) T cells.
MeSH terms
Animals; Antigen-Presenting Cells; Antigens; Bone Marrow; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dermis; Female; Immunologic Memory; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid Cells; Neutrophils; Receptors, CCR1
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