Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells.
Immunity, 2012/10/19;37(4):735-46.
Singh NJ[1], Bando JK, Schwartz RH
Affiliations
PMID: 23021952
Impact factor: 43.474
Abstract
After an immune response, the expanded population of antigen-specific CD4(+) T cells contract to steady state levels. We have found that the contraction is neither cell-autonomous nor mediated by competition for generic trophic factors, but regulated by relatively rare subsets of neighboring CD4(+) T cells not necessarily of a conventional regulatory T cell lineage. These regulators, referred to as deletors, specifically limit the frequency of particular antigen-specific T cells even though they are not reactive to the same agonist as their targets. Instead, an isolated deletor could outcompete the target for recognition of a shared, nonstimulatory endogenous peptide-MHC ligand. This mechanism was sufficient to prevent even agonist-driven autoimmune disease in a lymphopenic environment. Such a targeted regulation of homeostasis within narrow colonies of T cells with related TCR specificities for subthreshold ligands might help to prevent the loss of unrelated TCRs during multiple responses, preserving the valuable diversity of the repertoire.
MeSH terms
Animals; Antigens; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Ligands; Lymphopenia; Mice; Receptors, Antigen, T-Cell; T-Cell Antigen Receptor Specificity
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