Characterization of an influenza A virus in Mexican swine that is related to the A/H1N1/2009 pandemic clade.
Virology, 2012/11/10;433(1):176-82.
Escalera-Zamudio M[1], Cobián-Güemes G, de los Dolores Soto-del Río M, Isa P, Sánchez-Betancourt I, Parissi-Crivelli A, Martínez-Cázares MT, Romero P, Velázquez-Salinas L, Huerta-Lozano B, Nelson M, Montero H, Vinuesa P, López S, Arias CF
Affiliations
PMID: 22921315
Impact factor: 3.513
Abstract
In the spring of 2009, swine-origin influenza H1N1pdm09 viruses caused the first influenza pandemic of this century. We characterized the influenza viruses that circulated early during the outbreak in Mexico, including one newly sequenced swine H1N1pdm09 virus and three newly sequenced human H1N1pdm09 viruses that circulated in the outbreak of respiratory disease in La Gloria, Veracruz. Phylogenetic analysis revealed that the swine isolate (A/swine/Mexico/4/2009) collected in April 2009 is positioned in a branch that is basal to the rest of the H1N1pdm09 clade in two (NP and PA) of the eight single-gene trees. In addition, the concatenated HA-NA and the complete whole-genome trees also showed a basal position for A/swine/Mexico/4/2009. Furthermore, this swine virus was found to share molecular traits with non-H1N1pdm09 H1N1 viral lineages. These results suggest that this isolate could potentially be the first one detected from a sister lineage closely related to the H1N1pdm09 viruses.
MeSH terms
Animals; Humans; Influenza A Virus, H1N1 Subtype; Mexico; Molecular Typing; Multigene Family; Orthomyxoviridae Infections; Pandemics; Phylogeny; Swine; Viral Proteins
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