MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer.
FEBS Lett, 2012/7/30;586(16):2451-8.
He HC[1], Zhu JG, Chen XB, Chen SM, Han ZD, Dai QS, Ling XH, Fu X, Lin ZY, Deng YH, Qin GQ, Cai C, Chen JH, Zhong WD
Affiliations
PMID: 22710126DOI: 10.1016/j.febslet.2012.06.003
Impact factor: 3.864
Abstract
To investigate the mechanism by which peroxiredoxin III (PRDX3) is altered in human prostate cancer (PCa), we used microRNA (miRNA) target prediction program and miRNA microarray to predict and identify miR-23b as a candidate miRNA that targets PRDX3. We showed that miR-23b suppresses PRDX3 protein expression in human DU145 cells under normal and hypoxic conditions. Additionally, the clinical significance of miR-23b and PRDX3 expression in PCa patients was also confirmed. In conclusion, our data suggest that the effects of PRDX3 in PCa progression may be caused by the regulation function of miR-23b, and consequently, miR-23b may be involved in the response of PCa cells to hypoxia stress.
MeSH terms
Aged; Aged, 80 and over; Base Sequence; Cell Line, Tumor; Disease Progression; Disease-Free Survival; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; MicroRNAs; Middle Aged; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Peroxiredoxin III; Prostatic Neoplasms
More resources
EndNote: Download