Influence of exposure time on gene expression by human intestinal epithelial cells exposed to Lactobacillus acidophilus.
Appl Environ Microbiol, 2012/7;78(14):5028-32.
O'Flaherty S[1], Klaenhammer TR
Affiliations
PMID: 22562992DOI: 10.1128/AEM.00504-12
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Abstract
Analysis of global temporal gene expression by human intestinal cells when exposed to Lactobacillus acidophilus revealed induction of immune-related pathways and NF-κB target genes after a 1-h exposure, compared to a 4- or 8-h exposure. Additionally, an L. acidophilus derivative expressing covalently bound flagellin resulted in increased induction of il8, cxc1, and cxcl2 compared to the parent L. acidophilus.
MeSH terms
Caco-2 Cells; Epithelial Cells; Flagellin; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa; Intestines; Lactobacillus acidophilus; Molecular Sequence Data; NF-kappa B; Probiotics; Recombinant Proteins; Time Factors
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