RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family.
Antimicrob Agents Chemother, 2012/7;56(7):3960-2.
Galimand M[1], Courvalin P, Lambert T
Affiliations
PMID: 22547620DOI: 10.1128/AAC.00660-12
Impact factor: 5.938
Abstract
Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases.
MeSH terms
Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Klebsiella pneumoniae; Methyltransferases; Microbial Sensitivity Tests; Molecular Sequence Data; RNA, Ribosomal, 16S
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