pJIE137 carrying blaCTX-M-62 is closely related to p271A carrying blaNDM-1.
Antimicrob Agents Chemother, 2012/4;56(4):2166-8.
Partridge SR[1], Paulsen IT, Iredell JR
Affiliations
PMID: 22252811DOI: 10.1128/AAC.05796-11
Impact factor: 5.938
Abstract
Complete sequencing of pJIE137 revealed a backbone closely related to p271A, encoding a novel RepA protein but with a similar organization and up to ∼70% nucleotide identity to IncN plasmids. A region in pJIE137 resembling the IncN CUP regulon is mostly missing from p271A, presumably due to recombination. The class 1 In/Tn and ISEcp1-bla(CTX-M-62) transposition unit in pJIE137 and a putative transposon carrying bla(NDM-1) in p271A are inserted in different locations in the plasmid backbone.
MeSH terms
DNA, Bacterial; Genes, Bacterial; Klebsiella pneumoniae; Molecular Sequence Data; Mutagenesis, Insertional; Plasmids; Recombination, Genetic; Regulon; Terminology as Topic; beta-Lactamases
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