A natural deletion of the HoxC cluster in elasmobranch fishes.
Science, 2011/12/16;334(6062):1517.
King BL[1], Gillis JA, Carlisle HR, Dahn RD
Affiliations
PMID: 22174244DOI: 10.1126/science.1210912
Impact factor: 63.714
Abstract
Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of Hox genes into four paralogous clusters is a primitive feature of jawed vertebrates. By using high-throughput sequencing, we demonstrate the absence of all HoxC transcripts from embryos of the shark Scyliorhinus canicula and the skate Leucoraja erinacea and the absence of all HoxC genes and two HoxC-associated microRNAs from the genome of L. erinacea. These data suggest a loss of the entire HoxC cluster in elasmobranch fishes and represent evidence for the natural deletion of an entire Hox cluster in vertebrates.
MeSH terms
Animals; Gene Deletion; Gene Silencing; Homeodomain Proteins; MicroRNAs; Multigene Family; Sharks; Skates, Fish
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