A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus.
J Exp Med, 2011/12/19;208(13):2591-8.
Affiliations
PMID: 22110167DOI: 10.1084/jem.20110978
Impact factor: 17.579
Abstract
A primary function of B lymphocytes is immunoglobulin production; however, the therapeutic benefit of B cell depletion in autoimmune diseases previously thought to be T cell mediated suggests that some B cells fulfill other roles in autoimmunity. We examined the recently identified human B1 cell population for T cell stimulatory activity. We found two kinds of B1 cells that are distinguished by multiple surface markers and distinct transcriptomic profiles. In both umbilical cord and adult peripheral blood, a CD11b(+) subset constitutes ~1 out of every 8-10 B1 cells, whereas a CD11b(-) subset constitutes the remaining B1 cells. These B1 cell populations differ functionally. CD11b(-) B1 cells spontaneously secrete much more IgM than CD11b(+) B1 cells. In contrast, CD11b(+) B1 cells express more CD86, and more efficiently stimulate allogeneic CD4(+) T cell expansion, than CD11b(-) B1 cells. The frequency of these CD11b(+) B1 cells is markedly elevated in lupus patients. CD11b(+) B1 cells in lupus patients express more CD86 and have increased T cell-stimulating activity in disease. This work distinguishes a novel, T cell-interacting B1 cell population whose abundance and activity may be a reflection of, and a therapeutic target in, autoimmune disease.
MeSH terms
Adult; B-Lymphocyte Subsets; B7-2 Antigen; CD11b Antigen; CD4-Positive T-Lymphocytes; Female; Fetal Blood; Gene Expression Regulation; Humans; Immunoglobulin M; Lupus Erythematosus, Systemic; Lymphocyte Activation; Male; Middle Aged; Transcriptome
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download