Palladium-catalyzed Heck-type reactions of alkyl iodides.
J Am Chem Soc, 2011/12/21;133(50):20146-8.
Bloome KS[1], McMahen RL, Alexanian EJ
Affiliations
PMID: 22098504DOI: 10.1021/ja2091883
Impact factor: 16.383
Abstract
A palladium-catalyzed Heck-type reaction of unactivated alkyl iodides is described. This process displays broad substrate scope with respect to both alkene and alkyl iodide components and provides efficient access to a variety of cyclic products. The reaction is proposed to proceed via a hybrid organometallic-radical mechanism, facilitating the Heck-type process with alkyl halide coupling partners. Initial intermolecular studies are also reported, demonstrating the potentially wide applicability of this approach in synthesis.
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