Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6.
Diagn Microbiol Infect Dis, 2012/1;72(1):109-12.
Shigemoto N[1], Kuwahara R, Kayama S, Shimizu W, Onodera M, Yokozaki M, Hisatsune J, Kato F, Ohge H, Sugai M
Affiliations
PMID: 22078906DOI: 10.1016/j.diagmicrobio.2011.09.019
Impact factor: 2.983
Abstract
We identified 5 Klebsiella pneumoniae isolates showing high resistance to β-lactams except imipenem and designated them ISMRK (imipenem-susceptible but meropenem-resistant Klebsiella). They carried the bla(IMP-6) and bla(CTX-M-2) on a self-transmissible plasmid. ISMRK may be falsely categorized as susceptible to carbapenems if imipenem is used to screen carbapenem resistance.
MeSH terms
Aged, 80 and over; Anti-Bacterial Agents; Conjugation, Genetic; Female; Gene Transfer, Horizontal; Humans; Imipenem; Japan; Klebsiella Infections; Klebsiella pneumoniae; Male; Meropenem; Plasmids; Thienamycins; beta-Lactam Resistance; beta-Lactamases
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