Wide dissemination of Pseudomonas aeruginosa producing beta-lactamase blaKPC-2 gene in Colombia.
Antimicrob Agents Chemother, 2011/11;55(11):5350-3.
Cuzon G[1], Naas T, Villegas MV, Correa A, Quinn JP, Nordmann P
Affiliations
PMID: 21844315DOI: 10.1128/AAC.00297-11
Impact factor: 5.938
Abstract
Ten bla(KPC-2)-harboring Pseudomonas aeruginosa isolates from hospitals located in five different Colombian cities have been characterized. Isolates were multidrug resistant, belonged to five different pulsotypes, and possessed naturally chromosome-encoded bla(AmpC) and bla(OXA-50) genes and the acquired bla(KPC-2) gene. In most cases, the bla(KPC-2) genes were carried by plasmids of different sizes and were associated with Tn4401b or a new structure containing only part of the Tn4401 sequence. This study revealed that several clones of P. aeruginosa producing bla(KPC-2) are disseminating in Colombia.
MeSH terms
Anti-Bacterial Agents; Colombia; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Microbial Sensitivity Tests; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Pseudomonas aeruginosa; beta-Lactamases
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