Positive outcomes of oil palm phenolics on degenerative diseases in animal models.
Br J Nutr, 2011/12;106(11):1664-75.
Sambanthamurthi R[1], Tan Y, Sundram K, Hayes KC, Abeywardena M, Leow SS, Sekaran SD, Sambandan TG, Rha C, Sinskey AJ, Subramaniam K, Fairus S, Wahid MB
Affiliations
PMID: 21736778DOI: 10.1017/S0007114511002133
Impact factor: 4.125
Abstract
It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.
MeSH terms
Animals; Arrhythmias, Cardiac; Atherosclerosis; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Palm Oil; Phenols; Plant Oils; Rabbits; Rats; Rats, Inbred WKY
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