Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes.
Gene Ther, 2012/3;19(3):347-53.
Kim EY[1], Schulz R, Swantek P, Kunstman K, Malim MH, Wolinsky SM
Affiliations
PMID: 21697957DOI: 10.1038/gt.2011.95
Impact factor: 4.184
Abstract
The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems.
MeSH terms
Biological Transport; Cell Line; Gene Expression Profiling; Gene Expression Regulation; Gene Transfer Techniques; Gold; Humans; Immunity, Innate; Leukocytes, Mononuclear; Metal Nanoparticles; Oligonucleotides; Transcription, Genetic
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