Phylogenesis and Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection.
Open Virol J, 2011;5:22-6.
Ciccozzi M[1], Babakir-Mina M, Lo Presti A, Marcuccilli F, Perno CF, Ciotti M
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PMID: 21660186DOI: 10.2174/1874357901105010022
Abstract
During the spring of 2009, a new influenza A (H1N1) virus of swine origin emerged and spread worldwide causing a pandemic influenza. Here, 329 naso-pharyngeal swabs collected from patients with flu-like symptoms were analyzed by real-time PCR for the presence of H1N1 2009 pandemic virus. Twenty-five samples collected from immunocompetent and immunodepressed patients contained the H1N1 pandemic virus. Phylogenetic analysis of the hemagglutinin and neuraminidase genes showed no obvious differences in terms of similarity and/or homology between the sequences identified in immunocompetent individuals and those obtained from immunocompromised patients. Pre-existing clinical conditions may influence the outcome of H1N1 disease.
Keywords: H1N1 pandemic virus; influenza surface antigens.; phylogenetic analysis; respiratory infections; swine flu
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