The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
Nat Immunol, 2011/6;12(6):536-43.
Ise W[1], Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM
Affiliations
PMID: 21572431DOI: 10.1038/ni.2037
Impact factor: 31.25
Abstract
The transcription factor BATF controls the differentiation of interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) by regulating expression of the transcription factor RORγt itself and RORγt target genes such as Il17. Here we report the mechanism by which BATF controls in vivo class-switch recombination (CSR). In T cells, BATF directly controlled expression of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of follicular helper T cells (T(FH) cells). Restoring T(FH) cell activity to Batf(-/-) T cells in vivo required coexpression of Bcl-6 and c-Maf. In B cells, BATF directly controlled the expression of both activation-induced cytidine deaminase (AID) and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Thus, BATF functions at multiple hierarchical levels in two cell types to globally regulate switched antibody responses in vivo.
MeSH terms
Adaptor Proteins, Signal Transducing; Animals; B-Lymphocytes; Basic-Leucine Zipper Transcription Factors; CD40 Ligand; Carrier Proteins; Cells, Cultured; Cytidine Deaminase; Female; Flow Cytometry; Gene Expression Profiling; Germinal Center; Immunoglobulin Class Switching; Lymphocyte Activation; Male; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-bcl-6; Recombination, Genetic; T-Lymphocytes
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download