A novel gene cassette, aacA43, in a plasmid-borne class 1 integron.
Antimicrob Agents Chemother, 2011/6;55(6):2979-82.
Partridge SR[1], Thomas LC, Ginn AN, Wiklendt AM, Kyme P, Iredell JR
Affiliations
PMID: 21422220DOI: 10.1128/AAC.01582-10
Impact factor: 5.938
Abstract
A novel gene cassette, aacA43, was identified in the aadB-aacA43-oxa10-smr2 cassette array in a class 1 integron. Like related aminoglycoside-(6')-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL/M plasmid, aacA43 was identified in only two different Klebsiella pneumoniae strains (14 isolates), one Escherichia coli strain (2 isolates), and one Enterobacter cloacae strain in a survey of patients in a Sydney intensive care unit in 2004-2005.
MeSH terms
Acetyltransferases; Amino Acid Sequence; Base Sequence; Drug Resistance, Bacterial; Enterobacter cloacae; Escherichia coli; Humans; Integrons; Klebsiella pneumoniae; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction
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