Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico.
Emerg Infect Dis, 2011/2;17(2):283-6.
Ramirez-Gonzalez JE[1], Gonzalez-Duran E, Alcantara-Perez P, Wong-Arambula C, Olivera-Diaz H, Cortez-Ortiz I, Barrera-Badillo G, Nguyen H, Gubareva L, Lopez-Martinez I, Díaz-Quiñonez JA, Lezana-Fernández MA, Gatell-Ramírez HL, Cordova Villalobos JA, Hernández-Avila M, Alpuche-Aranda C
Affiliations
PMID: 21291607DOI: 10.3201/eid1702.100897
Impact factor: 16.126
Abstract
During May 2009-April 2010, we analyzed 692 samples of pandemic (H1N1) 2009 virus from patients in Mexico. We detected the H275Y substitution of the neuraminidase gene in a specimen from an infant with pandemic (H1N1) 2009 who was treated with oseltamivir. This virus was susceptible to zanamivir and resistant to adamantanes and oseltamivir.
MeSH terms
Adamantane; Antiviral Agents; Drug Resistance, Viral; Female; Humans; Infant; Influenza A Virus, H1N1 Subtype; Influenza, Human; Mexico; Microbial Sensitivity Tests; Neuraminidase; Oseltamivir; Pandemics; Point Mutation; Reverse Transcriptase Polymerase Chain Reaction; Zanamivir
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