Epigenetic changes in individuals with arsenicosis.
Chem Res Toxicol, 2011/2/18;24(2):165-7.
Smeester L[1], Rager JE, Bailey KA, Guan X, Smith N, García-Vargas G, Del Razo LM, Drobná Z, Kelkar H, Stýblo M, Fry RC
Affiliations
PMID: 21291286DOI: 10.1021/tx1004419
Impact factor: 3.973
Abstract
Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people worldwide, and chronically exposed individuals are susceptible to arsenicosis or arsenic poisoning. Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, and diabetes. Notably, we have uncovered an arsenic-induced tumor suppressorome, a complex of 17 tumor suppressors known to be silenced in human cancers. This finding represents a pivotal clue in unraveling a possible epigenetic mode of arsenic-induced disease.
MeSH terms
Arsenic; Arsenic Poisoning; CpG Islands; DNA Methylation; Environmental Exposure; Epigenesis, Genetic; Humans; Mexico; Water Pollutants, Chemical; Water Supply
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