Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.
J Bacteriol, 2010/9;192(17):4526-7.
Wang XJ[1], Yan YJ, Zhang B, An J, Wang JJ, Tian J, Jiang L, Chen YH, Huang SX, Yin M, Zhang J, Gao AL, Liu CX, Zhu ZX, Xiang WS
Affiliations
PMID: 20581206DOI: 10.1128/JB.00596-10
Impact factor: 3.476
Abstract
Streptomyces bingchenggensis is a soil-dwelling bacterium producing the commercially important anthelmintic macrolide milbemycins. Besides milbemycins, the insecticidal polyether antibiotic nanchangmycin and some other antibiotics have also been isolated from this strain. Here we report the complete genome sequence of S. bingchenggensis. The availability of the genome sequence of S. bingchenggensis should enable us to understand the biosynthesis of these structurally intricate antibiotics better and facilitate rational improvement of this strain to increase their titers.
MeSH terms
Anti-Bacterial Agents; Bacterial Proteins; Ethers; Genome, Bacterial; Macrolides; Molecular Sequence Data; Sequence Analysis, DNA; Spiro Compounds; Streptomyces
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