Integrative genomic profiling of human prostate cancer.
Cancer Cell, 2010/7/13;18(1):11-22.
Taylor BS[1], Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL
Affiliations
PMID: 20579941DOI: 10.1016/j.ccr.2010.05.026
Impact factor: 38.585
Abstract
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.
MeSH terms
Adult; Aged; Aged, 80 and over; Animals; Biomarkers, Tumor; Chromosomes, Human, Pair 3; Comparative Genomic Hybridization; Gene Dosage; Gene Expression Profiling; Genome, Human; Humans; Male; Mice; Middle Aged; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Fusion; Prostatic Neoplasms; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured
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