ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
EMBO Rep, 2010/7;11(7):541-7.
Krebs AR[1], Demmers J, Karmodiya K, Chang NC, Chang AC, Tora L
Affiliations
PMID: 20508642DOI: 10.1038/embor.2010.75
Impact factor: 9.071
Abstract
The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.
MeSH terms
Animals; Cells, Cultured; Chemokines, C; DNA-Binding Proteins; Fibroblasts; Gene Expression Regulation; Leucine Zippers; Mass Spectrometry; Mediator Complex; Mice; Mice, Knockout; Multiprotein Complexes; Peptides; Protein Subunits; RNA, Untranslated
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