ISEcp1-mediated transposition and homologous recombination can explain the context of bla(CTX-M-62) linked to qnrB2.
Antimicrob Agents Chemother, 2010/7;54(7):3039-42.
Zong Z[1], Partridge SR, Iredell JR
Affiliations
PMID: 20421399DOI: 10.1128/AAC.00041-10
Impact factor: 5.938
Abstract
bla(CTX-M-62), a C508T variant of bla(CTX-M-3b), was transferred from Klebsiella pneumoniae JIE137 on a conjugative plasmid together with a class 1 integron containing the dfrA12-gcuF-aadA2 cassette array, ISCR1, and qnrB2. bla(CTX-M-62) lies between intact and rearranged copies of ISEcp1 in a configuration that can be explained by a combination of transposition and homologous recombination and which also illustrates the ability of ISEcp1 to mobilize an adjacent gene as part of transposition units of different sizes.
MeSH terms
Anti-Bacterial Agents; Drug Resistance, Bacterial; Integrons; Klebsiella pneumoniae; Molecular Sequence Data; Plasmids; Recombination, Genetic
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