Orchestration of floral initiation by APETALA1.
Science, 2010/4/02;328(5974):85-9.
Kaufmann K[1], Wellmer F, Muiño JM, Ferrier T, Wuest SE, Kumar V, Serrano-Mislata A, Madueño F, Krajewski P, Meyerowitz EM, Angenent GC, Riechmann JL
Affiliations
PMID: 20360106DOI: 10.1126/science.1185244
Impact factor: 63.714
Abstract
The MADS-domain transcription factor APETALA1 (AP1) is a key regulator of Arabidopsis flower development. To understand the molecular mechanisms underlying AP1 function, we identified its target genes during floral initiation using a combination of gene expression profiling and genome-wide binding studies. Many of its targets encode transcriptional regulators, including known floral repressors. The latter genes are down-regulated by AP1, suggesting that it initiates floral development by abrogating the inhibitory effects of these genes. Although AP1 acts predominantly as a transcriptional repressor during the earliest stages of flower development, at more advanced stages it also activates regulatory genes required for floral organ formation, indicating a dynamic mode of action. Our results further imply that AP1 orchestrates floral initiation by integrating growth, patterning, and hormonal pathways.
MeSH terms
Arabidopsis; Arabidopsis Proteins; Binding Sites; Chromatin Immunoprecipitation; Down-Regulation; Flowers; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Genome, Plant; Homeodomain Proteins; MADS Domain Proteins; Oligonucleotide Array Sequence Analysis; Transcription Factors; Transcription Initiation Site; Transcription, Genetic; Transcriptional Activation
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