The complete genome sequence of Haloferax volcanii DS2, a model archaeon.
PLoS One, 2010/3/19;5(3):e9605.
Hartman AL[1], Norais C, Badger JH, Delmas S, Haldenby S, Madupu R, Robinson J, Khouri H, Ren Q, Lowe TM, Maupin-Furlow J, Pohlschroder M, Daniels C, Pfeiffer F, Allers T, Eisen JA
Affiliations
PMID: 20333302DOI: 10.1371/journal.pone.0009605
Impact factor: 3.752
Abstract
background: Haloferax volcanii is an easily culturable moderate halophile that grows on simple defined media, is readily transformable, and has a relatively stable genome. This, in combination with its biochemical and genetic tractability, has made Hfx. volcanii a key model organism, not only for the study of halophilicity, but also for archaeal biology in general.
methodology/principal findings: We report here the sequencing and analysis of the genome of Hfx. volcanii DS2, the type strain of this species. The genome contains a main 2.848 Mb chromosome, three smaller chromosomes pHV1, 3, 4 (85, 438, 636 kb, respectively) and the pHV2 plasmid (6.4 kb).
conclusions/significance: The completed genome sequence, presented here, provides an invaluable tool for further in vivo and in vitro studies of Hfx. volcanii.
MeSH terms
Amino Acids; Archaea; Chromosome Mapping; Codon; Computational Biology; Gene Library; Genome; Genome, Archaeal; Haloferax volcanii; Isoelectric Point; Open Reading Frames; Phylogeny; Sequence Analysis, DNA; Signal Transduction
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