Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells.
Nano Lett, 2010/1;10(1):143-8.
Peng L[1], Barczak AJ, Barbeau RA, Xiao Y, LaTempa TJ, Grimes CA, Desai TA
Affiliations
PMID: 20030358DOI: 10.1021/nl903043z
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Abstract
The response of primary human endothelial (ECs) and vascular smooth muscle cells (VSMCs) to TiO2 nanotube arrays is studied through gene expression analysis. Microarrays revealed that nanotubes enhanced EC proliferation and motility, decreased VSMC proliferation, and decreased expression of molecules involved in inflammation and coagulation in both cell types. Networks generated from significantly affected genes suggest that cells may be sensing nanotopographical cues via pathways previously implicated in sensing shear stress.
MeSH terms
Cell Adhesion; Cell Movement; Cell Proliferation; Endothelial Cells; Genome; Humans; Inflammation; Metal Nanoparticles; Muscle, Smooth, Vascular; Nanotubes; Phenotype; Stress, Mechanical; Titanium
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