New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria.
Antimicrob Agents Chemother, 2009/10;53(10):4518-21.
Schneider I[1], Queenan AM, Markovska R, Markova B, Keuleyan E, Bauernfeind A
Affiliations
PMID: 19620330DOI: 10.1128/AAC.00461-09
Impact factor: 5.938
Abstract
A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime, ceftazidime, and cefepime.
MeSH terms
Anti-Bacterial Agents; Bulgaria; Cefepime; Cefotaxime; Ceftazidime; Cephalosporins; Kinetics; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Sequence Data; beta-Lactamases
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