Repeated elements coordinate the spatial organization of the yeast genome.
Yeast, 2009/2;26(2):125-38.
O'Sullivan JM[1], Sontam DM, Grierson R, Jones B
Affiliations
PMID: 19235779DOI: 10.1002/yea.1657
Impact factor: 3.325
Abstract
The spatial organization of the chromosomes is crucial for gene expression and development. Inter- and intrachromosomal interactions form a crucial part of this epigenomic regulatory system. Here we use circular chromosome conformation capture-on-chip (4C) to identify interactions between repetitive and non-repetitive loci within the yeast genome. The interacting regions occur in non-randomly distributed clusters. Furthermore, the SIR2 histone deacetylase has opposing roles in the organization of the inter- or intrachromosomal interactions. These data establish a dynamic domain model for yeast genome organization. Moreover, they point to the repeated elements playing a central role in the dynamic organization of genome architecture.
MeSH terms
Cell Nucleolus; Cell Nucleus; Chromosome Positioning; DNA Transposable Elements; Gene Expression Regulation, Fungal; Genome, Fungal; Oligonucleotide Array Sequence Analysis; Repetitive Sequences, Nucleic Acid; Saccharomyces cerevisiae
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