Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice.
Br J Cancer, 2008/11/18;99(10):1729-34.
Pantaleo MA[1], Astolfi A, Nannini M, Paterini P, Piazzi G, Ercolani G, Brandi G, Martinelli G, Pession A, Pinna AD, Biasco G
Affiliations
PMID: 18827815DOI: 10.1038/sj.bjc.6604681
Impact factor: 9.075
Abstract
At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.
MeSH terms
Adult; Aged; Biomarkers, Tumor; Colorectal Neoplasms; ErbB Receptors; Female; Gene Expression Profiling; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasms, Multiple Primary; Neoplasms, Second Primary
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download