The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium.
J Bacteriol, 2008/10;190(19):6517-23.
Papp-Wallace KM[1], Nartea M, Kehres DG, Porwollik S, McClelland M, Libby SJ, Fang FC, Maguire ME
Affiliations
PMID: 18676664DOI: 10.1128/JB.00772-08
Impact factor: 3.476
Abstract
CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.
MeSH terms
Animals; Bacterial Proteins; Blotting, Western; Caco-2 Cells; Cation Transport Proteins; Humans; Magnesium; Mice; Mice, Inbred BALB C; Mutation; Oligonucleotide Array Sequence Analysis; Salmonella Infections, Animal; Salmonella typhimurium; Virulence
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