The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae.
Antimicrob Agents Chemother, 2008/9;52(9):3427-9.
Rice LB[1], Carias LL, Hutton RA, Rudin SD, Endimiani A, Bonomo RA
Affiliations
PMID: 18573935DOI: 10.1128/AAC.00493-08
Impact factor: 5.938
Abstract
The bla(KPC-3) and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae.
MeSH terms
Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Conjugation, Genetic; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Humans; Klebsiella pneumoniae; Molecular Sequence Data; Plasmids; Sequence Analysis, DNA; beta-Lactamases
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