Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2.
BMC Med Genomics, 2008/1/31;1:2.
Avasarala JR[1], Chittur SV, George AD, Tine JA
Affiliations
PMID: 18237449DOI: 10.1186/1755-8794-1-2
Impact factor: 3.622
Abstract
background: We investigated if global gene expression and transcription networks in B-lymphocytes of siblings with multiple sclerosis (MS) were different from healthy siblings.
results: Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.
conclusion: No study has linked TCF2 to MS and to better understand the role of TCF2 in MS, studies in larger cohorts are required.
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