LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.
J Bacteriol, 2008/1;190(2):759-63.
Agustiandari H[1], Lubelski J, van den Berg van Saparoea HB, Kuipers OP, Driessen AJ
Affiliations
PMID: 17993533
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Abstract
LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.
MeSH terms
ATP-Binding Cassette Transporters; DNA, Bacterial; Gene Deletion; Gene Expression Regulation, Bacterial; Lactococcus lactis; Multidrug Resistance-Associated Proteins; Protein Binding; Repressor Proteins
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