Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates.
Antimicrob Agents Chemother, 2006/12;50(12):4177-81.
Doloy A[1], Verdet C, Gautier V, Decré D, Ronco E, Hammami A, Philippon A, Arlet G
Affiliations
PMID: 16982793
Impact factor: 5.938
Abstract
We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.
MeSH terms
Base Sequence; Chromosomes, Bacterial; Cross Infection; DNA Transposable Elements; Enterobacteriaceae; Enterobacteriaceae Infections; Genes, Bacterial; Hafnia alvei; Humans; Integrons; Molecular Sequence Data; Open Reading Frames; Plasmids; beta-Lactamases
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