Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice.
Biol Chem, 2006/9;387(9):1219-26.
Frericks M[1], Temchura VV, Majora M, Stutte S, Esser C
Affiliations
PMID: 16972790
Impact factor: 4.7
Abstract
The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little is known about the effects of AHR deficiency on gene expression balance. We compared the transcriptome of CD4 T cells from AHR-/- mice and wild-type mice; 390 genes, many of them immunotypic, were deregulated in AHR-deficient CD4 cells. TCDD-induced transcriptome changes correlated with the AHR expression level in immune cells. However, there was little overlap in AHR-dependent transcripts found in T lineage cells or dendritic cells. Our results demonstrate flexible gene accessibility for the AHR in immune cells. The idea of a universal battery of AHR-responsive genes is not tenable.
MeSH terms
Animals; CD4-Positive T-Lymphocytes; Mice; Organ Specificity; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Structure-Activity Relationship; Transcription, Genetic
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