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16535371
Bactericidal mode of action of plantaricin C.

Appl Environ Microbiol, 1996/8;62(8):2701-9.

Gonzalez B, Glaasker E, Kunji E, Driessen A, Suarez JE, Konings WN

PMID: 16535371

Impact factor: 5.005

Abstract
Plantaricin C is a bacteriocin produced by Lactobacillus plantarum LL441 that kills sensitive cells by acting on the cytoplasmic membrane. In contrast to its lack of impact on immune cells, plantaricin C dissipates the proton motive force and inhibits amino acid transport in sensitive cells. In proteoliposomes, plantaricin C dissipates the transmembrane electrical potential, and in liposomes, it elicits efflux of entrapped carboxy-fluorescein. It is concluded that plantaricin C is a pore-forming bacteriocin that functions in a voltage-independent manner and does not require a specific protein receptor in the target membrane.
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