Progesterone concentration in placenta, molar tissue, and ovarian theca lutein cyst.
Obstet Gynecol, 1975/2;45(2):171-4.
PMID: 163995
Impact factor: 7.623
Abstract
Progesterone concentrations in 2 full-term normal placentas, molar tissue from 3 cases of hydatidiform mole were measured by competitive protein binding. Sephadex LH-20 column chromatographic separation of extracts from these tissues showed that, in placental and molar tissue, 85 to 95% of the extracts were progesterone and very small amounts of 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone. The concentration of progesterone in the placenta were 368.8 and 317.2 ng/g tissue, respectively, while in molar tissue the concentration were 2474.5, 1974.6, and 4146.0 ng/g tissue, respectively. Progesterone concentration in ovarian tissue was between 1121;2 and 1440.9 ng/g tissue. It is suggested that the high concentration of progesterone in molar tissue reflects functional capacity of the abnormal trophoblast in progesterone synthesis and accumulation of progesterone due to absence of a fetus. The lower concentration of progesterone in the ovary in molar pregnancy would appear to suggest that the ovary is a secondary source of progesterone in molar pregnancy.
MeSH terms
Chorionic Gonadotropin; Chromatography; Chromatography, Gel; Female; Humans; Hydatidiform Mole; Hydroxyprogesterones; Hysterectomy; In Vitro Techniques; Ovarian Neoplasms; Placenta; Pregnancy; Pregnancy Trimester, First; Progesterone; Thecoma
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