The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.
Nat Immunol, 2005/9;6(9):946-53.
Dostert C[1], Jouanguy E, Irving P, Troxler L, Galiana-Arnoux D, Hetru C, Hoffmann JA, Imler JL
Affiliations
PMID: 16086017
Impact factor: 31.25
Abstract
The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate members of the transcription factor NF-kappaB family. Here we have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways and triggered a signal transducer and activator of transcription (STAT) DNA-binding activity. Genetic experiments showed that the Jak kinase Hopscotch was involved in the control of the viral load in infected flies and was required but not sufficient for the induction of some virus-regulated genes. Our results indicate that in addition to Toll and Imd, a third, evolutionary conserved innate immunity pathway functions in drosophila and counters viral infection.
MeSH terms
Animals; Animals, Genetically Modified; DNA-Binding Proteins; Drosophila Proteins; Drosophila melanogaster; Insect Viruses; Janus Kinase 1; Male; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein-Tyrosine Kinases; STAT1 Transcription Factor; Signal Transduction; Trans-Activators
More resources
EndNote: Download