Oxidative stress in colon tissue induced by vitamin E depletion.
Biochem Soc Trans, 2004/12;32(Pt 6):979-81.
Drew JE[1], Mercer DK, Mayer C, Farquharson AJ, Morrice PC, Arthur JR, Duthie GG
Affiliations
PMID: 15506941
Impact factor: 4.919
Abstract
Inflammatory disorders of the bowel and colon cancer are associated with elevated indices of oxidative stress. Analogous elevations in markers of oxidative stress and loss of cell-membrane integrity are also observed in the colons of rats deficient in vitamin E (D-alpha-tocopherol), the major lipid-soluble antioxidant in biological systems. The causal relationship between colon pathologies associated with oxidative stress and dietary deficiency in antioxidant vitamins such as vitamin E is still uncertain. Investigation of potential mechanisms by which lack of dietary vitamin E may lead to clinically relevant pathological changes in colon tissue was conducted using gene expression profiling strategies on vitamin E-sufficient and -deficient rats. Morphological changes and increased indices of lipid peroxidation were linked to vitamin E deficiency. These changes in colon tissue are potentially important in disease pathogenesis of the colon linked with oxidative stress or other direct consequences of inadequate levels of vitamin E.
MeSH terms
Animals; Colon; Gene Expression Regulation; Lipid Peroxidation; Oxidative Stress; Rats; Rats, Inbred Strains; Vitamin E Deficiency; alpha-Tocopherol
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